Zhao DJ, Lu X, Jiang QY, Chen D, Zhou J, Yu H, Wang QQ, Tang GP
[Preparation of floxuridine loaded polycation and its antitumor activity.] [English Abstract, Journal Article]
Zhejiang Da Xue Xue Bao Yi Xue Ban 2009 Jan; 38(1):53-8.
OBJECTIVE: To develop a new prodrug of 5-fluorouracil-polyethylenimine-beta-cyclodextrin-floxuridine (PEI-beta-CyD-Fd) and to test its antitumor activity.
METHODS: Floxuridine was conjugated to polyethylenimine-beta-cyclodextrin to form prodrug PEI-beta-CyD-Fd. The structure of synthesized PEI-beta-CyD-Fd was confirmed by (1)H-NMR, FT-IR and UV. MTT assay and cell wound healing assay were performed on human hepatic carcinoma cell line HepG2.
RESULT: The drug loading was 2 %. The MTT assay and cell wound healing assay indicated that PEI-beta-CyD-Fd significantly inhibited proliferation and migration of HepG2 cells.
Conclusion: The synthesized prodrug PEI-CyD-Fd has a significant antitumor activity on HepG2 cells.
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